Van den Brink G, Schwartzenberg R R, Hoeve L J, Porsius A J, Hoeve L L
Department of Pharmacotherapy, Faculty of Pharmacy, University of Utrecht, The Netherlands.
Pharm World Sci. 1993 Jun 18;15(3):128-31. doi: 10.1007/BF02113941.
The medication of 582 patients taking insulin or oral hypoglycaemic agents has been analysed. A characterization is given of the patients and their antidiabetic medication. Subsequently, a description of the use of cardiovascular drugs, in comparison with an age-matched control group, is presented. The diabetic population investigated has an average age of 67 years. Most cardiovascular agents, with the exception of thiazide diuretics, are used to a larger extent in the diabetic group in comparison with the control group. Non-selective beta-blockers, possibly hazardous in patients with diabetes mellitus, appear to be prescribed without restriction in the diabetic patients investigated. The results of this study suggest that the choice of drugs for the treatment of cardiovascular co-morbidity in patients with diabetes mellitus can be improved.
对582名正在使用胰岛素或口服降糖药的患者的用药情况进行了分析。介绍了这些患者及其抗糖尿病药物的特征。随后,与年龄匹配的对照组相比,对心血管药物的使用情况进行了描述。所调查的糖尿病患者平均年龄为67岁。与对照组相比,除噻嗪类利尿剂外,大多数心血管药物在糖尿病组中的使用程度更高。非选择性β受体阻滞剂对糖尿病患者可能有危险,但在所调查的糖尿病患者中似乎无限制地开具。本研究结果表明,糖尿病患者心血管合并症治疗药物的选择可以得到改善。