Magliozzi J R, Maddock R J, Gold A S, Gietzen D W
Psychiatry Service, Albuquerque Veterans Affairs Medical Center, New Mexico.
Ann Clin Psychiatry. 1993 Jun;5(2):111-6. doi: 10.3109/10401239309148972.
Scores on rating scales measuring symptoms of depression, panic anxiety, state anxiety, trait anxiety, and agoraphobic avoidance were correlated, using multivariate statistics, with total thyroxine- and thyrotropin-releasing hormone concentrations in outpatients with major depression. A significant inverse relationship was demonstrated between agoraphobic avoidance and total thyroxine concentrations in female patients. No other symptom ratings were significantly associated with these thyroid indices. The depressed patients scored in the clinically significant range for agoraphobic symptoms. Assessment of agoraphobic avoidance may help identify a clinically and biologically distinct subgroup of depressed patients.
采用多变量统计方法，对重度抑郁症门诊患者中，测量抑郁症状、惊恐焦虑、状态焦虑、特质焦虑和广场恐怖回避症状的评定量表得分，与总甲状腺素和促甲状腺激素释放激素浓度进行相关性分析。结果显示，女性患者的广场恐怖回避与总甲状腺素浓度之间存在显著的负相关。其他症状评分与这些甲状腺指标均无显著相关性。抑郁症患者的广场恐怖症状评分处于临床显著范围内。评估广场恐怖回避情况可能有助于识别出临床上和生物学上有明显差异的抑郁症患者亚组。
