Pavcovich L A, Ramirez O A
Departamento de Farmacología, Facultad de Ciencias Quimicas, Universidad Nacional de Córdoba, Argentina.
Brain Res Bull. 1993;32(2):83-6. doi: 10.1016/0361-9230(93)90059-k.
One week after inescapable shock (IS) exposure, animals showed an increased number of escape failures in the shuttlebox and a decreased noradrenergic (NA) transmission. The latter was assessed by electric activity of locus coeruleus (LC) neurons. Seven daily injections of desipramine (DMI) were effective in reducing the number of escapes failures in the shuttlebox, but such treatment did not modify the decreased electric activity of LC NA neurons observed 7 days after IS. These results are discussed in terms of the action of DMI on NA terminals in reversing the behavioral deficit induced by IS.
在遭受不可逃避电击（IS）一周后，动物在穿梭箱中的逃避失败次数增加，去甲肾上腺素能（NA）传递减少。后者通过蓝斑（LC）神经元的电活动进行评估。每天注射七次地昔帕明（DMI）可有效减少穿梭箱中的逃避失败次数，但这种治疗并未改变IS后7天观察到的LC NA神经元电活动降低的情况。根据DMI对NA终末的作用来讨论这些结果，该作用可逆转IS诱导的行为缺陷。
