Underwood M J, De Bono D P
University Department of Cardiology, Glenfield General Hospital, Leicester, United Kingdom.
Cardiovasc Res. 1993 May;27(5):882-5. doi: 10.1093/cvr/27.5.882.
The aim was to quantify and compare the fibrinolytic activity of normal blood vessels (saphenous vein, internal mammary artery, and aorta) and atheromatous arteries (coronary endarterectomy specimens).
Fibrinolytic activity was measured by fibrin plate and colorimetric assays on fresh samples of coronary endarterectomy core, internal mammary artery, human aorta, and saphenous vein from patients undergoing coronary artery bypass surgery.
Fibrinolytic activity on fibrin plates ranked in the order endarterectomy cores > internal mammary artery > saphenous vein. The increased activity of endarterectomy cores was associated with an increased content of extractable tissue plasminogen activator and was suppressed by monoclonal antibody to tissue plasmogen activator. Paired comparisons of tissues from the same patients confirmed this increased activity in endarterectomy specimens relative to normal artery or vein. Urokinase activity was also increased in some endarterectomy specimens, but was more variable than tissue plasmogen activator.
The increased fibrinolytic activity of endarterectomy cores may help preserve patency in atheromatous vessels, but at the possible price of increased intimal instability and fibrous proliferation.
旨在量化并比较正常血管（大隐静脉、乳内动脉和主动脉）与动脉粥样硬化血管（冠状动脉内膜切除术标本）的纤溶活性。
采用纤维蛋白平板法和比色法，对接受冠状动脉搭桥手术患者的冠状动脉内膜切除术芯、乳内动脉、人主动脉和大隐静脉的新鲜样本进行纤溶活性测定。
纤维蛋白平板上的纤溶活性排序为：内膜切除术芯＞乳内动脉＞大隐静脉。内膜切除术芯活性增加与可提取的组织纤溶酶原激活物含量增加相关，并被组织纤溶酶原激活物单克隆抗体所抑制。对同一患者的组织进行配对比较证实，与正常动脉或静脉相比，内膜切除术标本中的活性增加。一些内膜切除术标本中的尿激酶活性也增加，但比组织纤溶酶原激活物更具变异性。
内膜切除术芯的纤溶活性增加可能有助于维持动脉粥样硬化血管的通畅，但可能以增加内膜不稳定性和纤维增生为代价。
