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组织型纤溶酶原激活剂在用作冠状动脉旁路移植自体移植物的人隐静脉中的定位与形态学变化的关系。

Localization of tissue plasminogen activator in relation to morphologic changes in human saphenous veins used as coronary artery bypass autografts.

作者信息

Glas-Greenwalt P, Dalton B C, Astrup T

出版信息

Ann Surg. 1975 Apr;181(4):431-41. doi: 10.1097/00000658-197504000-00012.

DOI:10.1097/00000658-197504000-00012
PMID:1079445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1343784/
Abstract

Employing the histochemical fibrin slide technique, we studied the localization of fibrinolytically active sites in relation to morphologic changes in saphenous veins used as coronary artery bypass autografts. Of veins from 100 patients undergoing surgery for coronary heart disease, 63 samples revealed well-demarcated intimal fibrinolytic activity. Distinct foci of lysis were present in the media and adventitia of all vein samples corresponding to the distribution of the vasa vasorum. Graft specimens obtained by autopsy from 13 patients surviving from 30 minutes to 13 days revealed considerable intimal damage with loss of fibrinolytic activity. Medial fibrinolytic activity disappeared early concomitant with disorganization of the medial muscle fibers, followed by necrosis, atrophy and fibrous transformation of the muscular structures. Adventitial activity disappeared later. One reoperation sample obtained after 8 weeks in situ showed moderate proliferative intimal fibrosis without an apparent neo-intima and without fibrinolytic activity, and one section showed evidence of valve cusp fibrosis, while most of the media had been replaced by fibrous tissue. Numerous foci of "medial" -adventitial fibrinolytic activity indicated presence of vascular structures in the venous wall. The fibrin slide technique is a convenient tool for studying the process of revascularization.

摘要

采用组织化学纤维蛋白玻片技术，我们研究了用作冠状动脉旁路自体移植物的大隐静脉中纤维蛋白溶解活性位点的定位与形态学变化的关系。在100例接受冠心病手术的患者的静脉中，63个样本显示出界限分明的内膜纤维蛋白溶解活性。在所有静脉样本的中膜和外膜中均存在与血管滋养管分布相对应的明显溶解灶。对13例存活30分钟至13天的患者进行尸检获得的移植物标本显示，内膜有相当程度的损伤，纤维蛋白溶解活性丧失。中膜纤维蛋白溶解活性早期消失，同时中膜肌纤维紊乱，随后肌肉结构发生坏死、萎缩和纤维性转化。外膜活性稍后消失。1个原位8周后获得的再次手术样本显示中度增生性内膜纤维化，无明显新生内膜且无纤维蛋白溶解活性，1个切片显示瓣膜尖纤维化证据，而大部分中膜已被纤维组织取代。大量“中膜”-外膜纤维蛋白溶解活性灶表明静脉壁中存在血管结构。纤维蛋白玻片技术是研究血管重建过程的便捷工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/d1af95e589d6/annsurg00290-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/a919ab4bd727/annsurg00290-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/d2ac7a6ae36a/annsurg00290-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/09e676cc1bb4/annsurg00290-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/b24bf41bf25c/annsurg00290-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/bf4cd9da3bc4/annsurg00290-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/674e257027d1/annsurg00290-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/c824c9afcc53/annsurg00290-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/d1af95e589d6/annsurg00290-0077-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/a919ab4bd727/annsurg00290-0070-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/d2ac7a6ae36a/annsurg00290-0070-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/09e676cc1bb4/annsurg00290-0071-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/b24bf41bf25c/annsurg00290-0073-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/bf4cd9da3bc4/annsurg00290-0074-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/674e257027d1/annsurg00290-0075-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/c824c9afcc53/annsurg00290-0076-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0966/1343784/d1af95e589d6/annsurg00290-0077-a.jpg

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本文引用的文献

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The Effects on Venous Endothelium of Alterations in Blood Flow Through the Vessels in Vein Walls, and the Possible Relation to Thrombosis.血流改变对静脉壁血管中静脉内皮的影响及其与血栓形成的可能关系。
Ann Surg. 1947 Sep;126(3):270-88.
2
Study of revascularization of blood vessel grafts by means of radioactive phosphorus.利用放射性磷对血管移植物血管再生的研究。
AMA Arch Surg. 1952 Sep;65(3):477-86. doi: 10.1001/archsurg.1952.01260020491017.
3
The nutrition of blood vessel grafts. An India ink injection study of their vascularization.
Ann Surg. 1985 Jul;202(1):50-5. doi: 10.1097/00000658-198507000-00007.
4
Degenerative changes of vein grafts in preparation media: preliminary studies by electron microscopy and fibrinolytic autography.制备介质中静脉移植物的退行性变化：电子显微镜和纤维蛋白溶解自显影术的初步研究
Jpn J Surg. 1978 Dec;8(4):333-41. doi: 10.1007/BF02469416.
Surg Gynecol Obstet. 1952 Mar;94(3):311-6.
4
SUCCESSFUL ENDOPHLEBECTOMY OF AUTOGENOUS VENOUS BYPASS GRAFT.自体静脉搭桥移植血管成功进行血管内膜切除术
Ann Surg. 1965 Aug;162(2):251-4. doi: 10.1097/00000658-196508000-00013.
5
THE VASCULARIZATION OF VEIN-GRAFTS.静脉移植物的血管化
Br J Surg. 1964 May;51:378-81. doi: 10.1002/bjs.1800510522.
6
Origin of blood fibrinolytic activity from veins and its bearing on the fate of venous thrombi.静脉血纤维蛋白溶解活性的来源及其与静脉血栓转归的关系。
Lancet. 1963 Jun 15;1(7294):1288-90. doi: 10.1016/s0140-6736(63)91984-6.
7
Thromboplastic and fibrinolytic activities of large human vessels.
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8
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9
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10
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