Hrstková H, Stavratjev M
I. dĕtská klinika LF Masarykovy univerzity, Brno.
Cesk Pediatr. 1993 Jun;48(6):313-7.
Acute lymphoblastic leukaemia (ALL) is one of the readily treatable neoplastic diseases of childhood. One of the late sequelae of treatment can be impaired growth. The authors followed up therefore a group of 63 patients where during childhood a diagnosis of ALL was made. The investigated group was treated according to two fundamental protocols--according to Pinkel's protocol and according to BMF protocols. All patients treated according to Pinkel's protocol had, as part of prevention of leukaemia of the CNS, radiotherapy of the skull, patients treated according to the BMF protocol only when the risk factor was higher than 0.8. The authors investigated in their patients the height and proportionality after termination of all antileukaemic therapy. They found that the height of children, adolescents and adults who suffered from ALL during childhood is average or less. A tendency towards obesity is typical. The authors did not observe a correlation with the total cumulative doses of cytostatics nor a marked correlation with radiotherapy. Impaired growth was more frequent when ALL was diagnosed before the age of 3 years and where the interval after completed therapy was shorter.
急性淋巴细胞白血病（ALL）是儿童期易于治疗的肿瘤性疾病之一。治疗的晚期后遗症之一可能是生长发育受损。因此，作者对一组63例在儿童期被诊断为ALL的患者进行了随访。研究组根据两种基本方案进行治疗——根据平克尔方案和根据BMF方案。按照平克尔方案治疗的所有患者，作为预防中枢神经系统白血病的一部分，都接受了颅骨放疗，按照BMF方案治疗的患者仅在危险因素高于0.8时才进行放疗。作者在所有抗白血病治疗结束后，对患者的身高和比例进行了调查。他们发现，童年时期患ALL的儿童、青少年和成年人的身高处于平均水平或更低。典型的情况是有肥胖倾向。作者没有观察到与细胞抑制剂的总累积剂量之间的相关性，也没有观察到与放疗之间的显著相关性。在3岁前被诊断为ALL且完成治疗后的间隔时间较短的情况下，生长发育受损更为常见。
