Morrissey S P, Miller D H, Hermaszewski R, Rudge P, MacManus D G, Kendall B, McDonald W I
Institute of Neurology, London, UK.
Eur Neurol. 1993;33(4):287-93. doi: 10.1159/000116956.
Magnetic resonance imaging (MRI) was performed in 25 patients with Behçet's disease, of whom 15 had clinical involvement of the central nervous system (CNS). Brain MRI was abnormal in 11/15 with and in 1/10 without CNS involvement. The most common sites of MR lesions were the cerebral white matter and brainstem. Lesions were also seen in the basal ganglia, cerebellum, optic nerves and spinal cord. The cerebral white matter lesions were always asymptomatic and usually small, whereas the brainstem lesions were often symptomatic and sometimes extensive. Follow-up MRI in 2 patients presenting with brainstem syndromes and treated with immunosuppression showed resolution of a large lesion in 1 patient in whom there was clinical remission, and the development of marked brainstem atrophy in the other who became severely disabled. The pattern of MRI abnormalities may assist the diagnosis and suggests a role for MRI in monitoring the effect of treatment in patients with neurological Behçet's disease.
对25例白塞病患者进行了磁共振成像（MRI）检查，其中15例有中枢神经系统（CNS）临床受累。15例中有11例脑部MRI异常，10例无CNS受累者中有1例异常。MRI病变最常见的部位是脑白质和脑干。基底节、小脑、视神经和脊髓也可见病变。脑白质病变通常无症状且较小，而脑干病变常伴有症状，有时范围广泛。2例出现脑干综合征并接受免疫抑制治疗的患者，随访MRI显示1例临床缓解患者的大病灶消退，另1例严重残疾患者出现明显的脑干萎缩。MRI异常模式可能有助于诊断，并提示MRI在监测神经白塞病患者治疗效果方面的作用。
