Cohard M, Rolachon A, Vetter D, Lejeune J M, Stierle J P, Fratte S, Doffoël M, Charachon R, Zarski J P
Clinique d'Hépato-Gastroentérologie, CHRU, Grenoble.
Gastroenterol Clin Biol. 1993;17(5):391-4.
Association of autoimmune cochlear hearing loss with primary sclerosing cholangitis is reported in two patients. Endocochlear sensorineural hearing loss was associated with the presence of anti-cochlear antibodies in the serum directed against the walls of vessels in the stria vascularis. The hearing loss appeared at the same time or shortly after the diagnosis of cholangitis. This association, which has never been described, may reinforce the theory of the role of immunologic factors in the pathogenesis of primary sclerosing cholangitis, possibly linked to or initiated by vasculitis.
两名患者被报道患有自身免疫性耳蜗性听力损失与原发性硬化性胆管炎相关。内耳感音神经性听力损失与血清中针对血管纹血管壁的抗耳蜗抗体的存在有关。听力损失在胆管炎诊断的同时或之后不久出现。这种从未被描述过的关联可能会强化免疫因素在原发性硬化性胆管炎发病机制中的作用理论，可能与血管炎有关或由血管炎引发。
