Romdhane Hayfa, Karoui Sami, Serghini Meriem, Boubaker Jalel, Filali Azza
Service de Gastroentérologie A, Hôpital la Rabta, Tunis.
Tunis Med. 2009 May;87(5):349-51.
Inflammatory bowel diseases are frequently associated with extra-intestinal manifestations and other autoimmune disorders. Association between primary sclerosing cholangitis and Crohn's disease is established. However, the association of antiphospholipid syndrome with Crohn's disease was reported in the literature only in the form of isolated case reports.
To report a Tunisian case of association of Crohn's disease, primary sclerosing cholangitis and antiphospholipid syndrome.
We report the case of a patient presenting a colonic Crohn's disease associated with primary sclerosing cholangitis and antiphospholipid syndrome. Sclerosing cholangitis was diagnosed basing on disturbances of the hepatic biochemical tests. Antiphospholipid syndrome was revealed by a venous thrombosis of the lower limbs.
Although the anticardiolipin antibodies were frequently found during the course of primary sclerosing cholangitis, the association with antiphospholipid syndrome is exceptionally described. In the same way, triple association of primary sclerosing cholangitis, Crohn's disease and antiphospholipid syndrome was not brought back in the literature.
炎症性肠病常伴有肠外表现及其他自身免疫性疾病。原发性硬化性胆管炎与克罗恩病之间的关联已得到证实。然而，抗磷脂综合征与克罗恩病的关联在文献中仅以个别病例报告的形式出现。
报告一例突尼斯患者，其患有克罗恩病、原发性硬化性胆管炎和抗磷脂综合征。
我们报告了一例患有结肠克罗恩病并伴有原发性硬化性胆管炎和抗磷脂综合征的患者。根据肝脏生化检查结果诊断为硬化性胆管炎。下肢静脉血栓形成提示抗磷脂综合征。
虽然在原发性硬化性胆管炎病程中经常发现抗心磷脂抗体，但与抗磷脂综合征的关联却鲜有报道。同样，原发性硬化性胆管炎、克罗恩病和抗磷脂综合征的三联关联在文献中也未见报道。
