Martínez F, Castillo J, Leira R, Prieto J M, Lema M, Noya M
Department of Neurology, Hospital General de Galicia, Clinico Universitario, Santiago de Compostela, Spain.
Headache. 1993 Jun;33(6):324-7. doi: 10.1111/j.1526-4610.1993.hed3306324.x.
Taurine is the amino acid with the highest concentration in the human body. Its physiologic functions are not yet well understood. As a neurotransmitter or neuromodulator it may display inhibitory functions. We have measured taurine levels in plasma and cerebrospinal fluid of migraine patients during attacks, comparing them with controls. Patients with migraine had significantly higher concentrations than controls. No sex or age influence over the amino acid levels were observed. Plasma taurine levels in patients with classic migraine correlated negatively with severity of headache. Central taurine liberation during migraine crisis may be due to spontaneous depolarization or a defensive reaction in the context of cerebral homeostatic processes.
牛磺酸是人体内浓度最高的氨基酸。其生理功能尚未完全明确。作为一种神经递质或神经调节剂，它可能具有抑制功能。我们测量了偏头痛患者发作期间血浆和脑脊液中的牛磺酸水平，并与对照组进行了比较。偏头痛患者的浓度显著高于对照组。未观察到性别或年龄对氨基酸水平有影响。典型偏头痛患者的血浆牛磺酸水平与头痛严重程度呈负相关。偏头痛发作时中枢牛磺酸的释放可能是由于自发去极化或脑内稳态过程中的一种防御反应。
