Kannan S, Balaram P, Chandran G J, Pillai M R, Mathew B, Nair M K
Division of Cancer Research, Regional Cancer Centre, Thiruvananthapuram, India.
J Cancer Res Clin Oncol. 1993;119(11):689-94. doi: 10.1007/BF01215989.
The binding pattern of two lectins, concanavalin A (ConA) and peanut agglutin (PNA), in various phases of tumour progression in the oral epithelium was studied. These included non-dysplastic, dysplastic and neoplastic lesions as well as normal tissue. ConA and PNA showed intense staining in the basement membrane of all types of lesions. Little difference was observed in the staining patterns between different stages of oral carcinogenesis, either with ConA or PNA. ConA showed mild cytoplasmic and membrane staining in all types of lesions while PNA showed moderate to intense staining in both the cytoplasm and membrane of lower-layer cells in all histological groups. The present study therefore shows that these lectins have limited value in the elucidation of oral carcinogenesis and are of insignificant diagnostic value.
研究了两种凝集素，即伴刀豆球蛋白A（ConA）和花生凝集素（PNA）在口腔上皮肿瘤进展各阶段的结合模式。这些阶段包括非发育异常、发育异常和肿瘤性病变以及正常组织。ConA和PNA在所有类型病变的基底膜中均显示出强烈染色。在口腔癌发生的不同阶段，无论是ConA还是PNA，其染色模式均未观察到明显差异。ConA在所有类型病变中均显示出轻度的细胞质和细胞膜染色，而PNA在所有组织学组的下层细胞的细胞质和细胞膜中均显示出中度至强烈染色。因此，本研究表明，这些凝集素在阐明口腔癌发生方面价值有限，诊断价值不大。
