多因素小鼠模型中血浆胆固醇水平与肥胖的基因座重合情况。
Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model.
作者信息
Warden C H, Fisler J S, Pace M J, Svenson K L, Lusis A J
机构信息
Department of Medicine, University of California Los Angeles, 90024.
出版信息
J Clin Invest. 1993 Aug;92(2):773-9. doi: 10.1172/JCI116649.
Abstract
We have examined backcross progeny derived from a cross of Mus spretus with C57BL/6J, that range from 1 to 50% carcass lipid (n = 215), and from 22 to 130 mg/dl plasma total cholesterol (n = 238). Statistical analysis revealed that distal mouse chromosome 7 exhibits significant linkage both to plasma total cholesterol (likelihood of the odds [LOD] 5.8) and to carcass lipid (LOD 3.8). A locus on chromosome 6 also shows significant linkage to plasma total cholesterol (LOD 5.6), but no linkage to carcass lipid. Neither chromosomal region contains any previously mapped genes likely to influence lipoprotein metabolism, indicating that novel genetic factors contributing to plasma lipoprotein levels have been identified.
摘要
我们检测了源自西班牙小家鼠与C57BL/6J杂交的回交后代，其胴体脂质含量在1%至50%之间（n = 215），血浆总胆固醇水平在22至130毫克/分升之间（n = 238）。统计分析表明，小鼠7号染色体远端与血浆总胆固醇（优势对数[LOD]为5.8）和胴体脂质（LOD为3.8）均表现出显著的连锁关系。6号染色体上的一个位点也与血浆总胆固醇表现出显著的连锁关系（LOD为5.6），但与胴体脂质无连锁关系。这两个染色体区域均不包含任何先前定位的可能影响脂蛋白代谢的基因，这表明已鉴定出影响血浆脂蛋白水平的新遗传因素。
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