X染色体上的一个基因座与小鼠的体长相关。

A locus on the X chromosome is linked to body length in mice.

作者信息

Lembertas A V, Fisher J S, Warden C H, Wen P Z, Xia Y R, Lusis A J

机构信息

Department of Medicine, University of California, Los Angeles, USA.

出版信息

Mamm Genome. 1996 Mar;7(3):171-3. doi: 10.1007/s003359900048.

DOI:10.1007/s003359900048

PMID:8833234

Abstract

Linkage between body length (anus to nose (AN) length) and three markers on the mouse X Chromosome was found in an interspecific backcross ((C57BL/6J x Mus spretus) F 1x C57BL/6J), designated BSB. A cross of 409 mice were scored for 148 genetic markers distributed on all chromosomes except the Y Chromosome. Statistical analysis revealed highly significant linkage (LOD score 5.5) between body length and a locus in the middle portion of the X Chromosome, the nearest markers being the microsatellite marker DXMit73 and a farnesyl pyrophosphate locus (Fpsl9) 3.1 cM proximal to DXMit73. The locus explains 10% of the variance in AN length and affects both males and females to about the same extent.

摘要

在一个种间回交群体（（C57BL/6J×小家鼠）F1×C57BL/6J），即指定的BSB群体中，发现了体长（肛门到鼻尖（AN）长度）与小鼠X染色体上三个标记之间的连锁关系。对409只小鼠的杂交后代进行了评分，以检测分布在除Y染色体外所有染色体上的148个遗传标记。统计分析显示，体长与X染色体中部的一个位点之间存在高度显著的连锁关系（LOD分数为5.5），最接近的标记是微卫星标记DXMit73和位于DXMit73近端3.1 cM处的法尼基焦磷酸位点（Fpsl9）。该位点解释了AN长度变异的10%，对雄性和雌性的影响程度大致相同。