Hartmann E E, Succop A, Buck S L, Weiss A H, Teller D Y
Division of Ophthalmology, Children's Hospital and Medical Center, Seattle, Washington 98105.
J Opt Soc Am A Opt Image Sci Vis. 1993 Aug;10(8):1835-40. doi: 10.1364/josaa.10.001835.
When tested monocularly, strabismic and amblyopic subjects often show asymmetries of optokinetic nystagmus (OKN), with OKN being more readily elicited by temporal-to-nasal than by nasal-to-temporal stimulus motion. We tested five visually normal subjects and ten strabismic and/or amblyopic subjects by use of motion-nulling stimuli, which consisted of superimposed temporal-to-nasal and nasal-to-temporal sinusoidal-grating components with a summed contrast of 100%. Both the direction of OKN and the subject's perceived direction of motion (PDM) were tested. Most normal subjects showed symmetrical OKN and PDM, but a rightward OKN bias was observed in one of the visually normal subjects. Temporal-to-nasal eye-movement biases were seen in most strabismic and amblyopic subjects, whereas PDM biases were smaller and less frequent. The primary purpose of this study was to demonstrate the feasibility of quantifying OKN and PDM asymmetries in a diverse group of visually abnormal adults by use of the motion-nulling technique. Application of this technique to larger and more homogeneous clinical populations may contribute to the continued differentiation and characterization of variants of the visual disorders associated with strabismus and amblyopia and with other defects of binocular vision.
单眼测试时，斜视和弱视患者通常表现出视动性眼震（OKN）不对称，与鼻颞向刺激运动相比，颞鼻向刺激运动更容易诱发OKN。我们使用运动抵消刺激对5名视力正常的受试者和10名斜视和/或弱视受试者进行了测试，该刺激由叠加的颞鼻向和鼻颞向正弦光栅成分组成，总对比度为100%。同时测试了OKN的方向和受试者的运动感知方向（PDM）。大多数正常受试者表现出对称的OKN和PDM，但在一名视力正常的受试者中观察到向右的OKN偏差。大多数斜视和弱视受试者存在颞鼻向眼球运动偏差，而PDM偏差较小且频率较低。本研究的主要目的是证明使用运动抵消技术量化不同组视力异常成年人中OKN和PDM不对称性的可行性。将该技术应用于更大且更同质的临床群体可能有助于持续区分和表征与斜视、弱视以及其他双眼视觉缺陷相关的视觉障碍变体。
