低剂量亚叶酸不干扰甲氨蝶呤对类风湿关节炎的疗效：一项为期8周的随机安慰剂对照试验。
Low dose leucovorin does not interfere with the efficacy of methotrexate in rheumatoid arthritis: an 8 week randomized placebo controlled trial.
作者信息
Weinblatt M E, Maier A L, Coblyn J S
机构信息
Department of Rheumatology and Immunology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
出版信息
J Rheumatol. 1993 Jun;20(6):950-2.
OBJECTIVE
To determine if simultaneously administered low dose leucovorin interferes with the efficacy of methotrexate (MTX).
METHODS
An 8-week double blind placebo controlled study of leucovorin (1 mg) in 16 patients with rheumatoid arthritis receiving chronic MTX was performed at a single academic center.
RESULTS
A flare of disease activity was not observed. Clinical variables of arthritis activity did not change in the leucovorin treated population.
CONCLUSIONS
Low dose leucovorin when taken simultaneously with MTX did not interfere with the efficacy of MTX in a short term 8 week trial.
目的
确定同时给予低剂量亚叶酸钙是否会干扰甲氨蝶呤（MTX）的疗效。
方法
在一个学术中心对16名接受慢性MTX治疗的类风湿关节炎患者进行了一项为期8周的双盲安慰剂对照研究，给予亚叶酸钙（1毫克）。
结果
未观察到疾病活动度的突然加剧。在接受亚叶酸钙治疗的人群中，关节炎活动的临床变量没有变化。
结论
在为期8周的短期试验中，低剂量亚叶酸钙与MTX同时服用时，不会干扰MTX的疗效。
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