Tator C H
Surg Neurol. 1977 Feb;7(2):73-7.
Chemotherapy experiments were performed with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in an experimental mouse brain tumor model. Cell suspensions of a transplantable mouse ependymoblastoma were injected intracerebrally by means of a stereotactic frame. CCNU was given either intraperitoneally or by direct intraneoplastic injection beginning the fifth day after tumor cell implantation. Intraneoplastic injection beginning the fifth day after tumor cell implantation. Intraneoplastic injections of drugs were made with the stereotactic frame. A single intraneoplastic injection of CCNU was found to be highly effective in increasing the median day of death and in yielding large numbers of long-term survivors. In some experiments CCNU injected into the neoplasm produced increased numbers of long-term survivors and less systemic toxicity than when injected intraperitoneally.
在实验性小鼠脑肿瘤模型中，使用1-(2-氯乙基)-3-环己基-1-亚硝基脲（CCNU）进行了化疗实验。通过立体定向框架将可移植性小鼠室管膜母细胞瘤的细胞悬液脑内注射。在肿瘤细胞植入后的第五天开始，CCNU通过腹腔注射或直接瘤内注射给药。在肿瘤细胞植入后的第五天开始进行瘤内注射。使用立体定向框架进行药物的瘤内注射。发现单次瘤内注射CCNU在延长中位死亡天数和产生大量长期存活者方面非常有效。在一些实验中，与腹腔注射相比，将CCNU注入肿瘤内产生了更多的长期存活者且全身毒性更小。
