Pertuiset B F, Pouillart P, Poisson M, Asselain B, Buge A
Sem Hop. 1981;57(5-6):245-52.
Glioma 26 (G26) is a chemically induced ependymoblastoma of mouse. It was used through sub-cutaneous and/or intracranial injection in 7 experiences which showed that this experimental model was able to select drugs acting on intracranial tumors : nitrosourea (CCNU), VM 26, procarbazine (PCB). Combination chemotherapy (VM 26-CCNU ; VM 26 CCNU-PCB) was more active than monochemotherapy in 2 out of 3 experiences. It seems that the variability of the results is at least partly due to the important tumoral necrosis in tumors treated by combination chemotherapy and to technical problems. The latters can be avoided by the mechanical dispersion of tumor cells and by their injection through a stereotaxic frame. Selection of drugs is easier and cheaper to perform with G 26 than with other in vivo and in vitro experimental models. The main problem for all models remains their lack of specificity.
胶质瘤26（G26）是一种化学诱导的小鼠室管膜母细胞瘤。在7次实验中通过皮下和/或颅内注射使用了该肿瘤，结果表明该实验模型能够筛选出作用于颅内肿瘤的药物：亚硝基脲（CCNU）、VM 26、丙卡巴肼（PCB）。在3次实验中的2次，联合化疗（VM 26 - CCNU；VM 26 - CCNU - PCB）比单一化疗更有效。结果的变异性似乎至少部分归因于联合化疗治疗的肿瘤中重要的肿瘤坏死以及技术问题。通过肿瘤细胞的机械分散以及通过立体定向框架进行注射可以避免这些技术问题。与其他体内和体外实验模型相比，使用G26进行药物筛选更容易且成本更低。所有模型的主要问题仍然是它们缺乏特异性。
