Bhatavdekar J M, Patel D D, Karelia N H, Suthar T P, Shah N G, Vora H H, Ghosh N, Nadkarni S P, Balar D B
Division of Research, Gujarat Cancer Society, Asarwa, Ahmedabad, India.
Neoplasma. 1993;40(3):177-80.
Estrogen and progesterone receptors (ER and PR) were estimated in 129 synchronous (primary and metastatic lymph node) breast cancer tissues, of which 40% were premenopausal and 60% were postmenopausal. ER and PR accordance was seen in 68% and 70% patients, and ER and PR discordance was seen in 32% and 30%, respectively. The mean level of ER in patients having ER accordance was higher in responders than in nonresponders. In patients having steroid receptors in accordance, there was a trend towards gain of receptors (type II) in responders, and loss of receptors (type I) in nonresponders. In ER discordant cases 48% were of type I while in PR discordant cases 46% were of type I. In postmenopausal patients, survival was lower in patients showing accordance than in those showing discordance. In nonresponders showing loss of receptors in lymph node, the survival was shorter than in those who showed gain of receptors in lymph node. No such trend was seen in premenopausal patients. Our study suggests that in postmenopausal patients, survival was better related to ER accordance than ER discordance and PR accordance or discordance. However, a larger patient series is needed for confirmation.
在129例同步（原发灶和转移淋巴结）乳腺癌组织中检测了雌激素受体（ER）和孕激素受体（PR），其中40%为绝经前患者，60%为绝经后患者。ER和PR符合率分别在68%和70%的患者中出现，ER和PR不符合率分别在32%和30%的患者中出现。ER符合的患者中，反应者的ER平均水平高于无反应者。在类固醇受体符合的患者中，反应者有受体增加（II型）的趋势，无反应者有受体减少（I型）的趋势。在ER不符合的病例中，48%为I型，而在PR不符合的病例中，46%为I型。在绝经后患者中，符合的患者生存率低于不符合的患者。在淋巴结中显示受体减少的无反应者中，生存率低于淋巴结中显示受体增加的患者。绝经前患者未观察到这种趋势。我们的研究表明，在绝经后患者中，生存率与ER符合的相关性优于ER不符合以及PR符合或不符合。然而，需要更大规模的患者系列来证实这一点。
