Tatake R J, Zeff R A
Department of Pathology, University of Connecticut Health Center, Farmington 06030.
Proc Soc Exp Biol Med. 1993 Sep;203(4):405-17. doi: 10.3181/00379727-203-43616a.
The major histocompatibility complex (MHC) class I gene products are known to play a fundamental role in foreign antigen presentation to the cellular immune system. Much attention has been directed to the study of MHC class I gene expression as a means to understanding the processes by which MHC class I-mediated immune responses are regulated. Two areas of considerable interest have emerged, including regulation at the levels of transcriptional control and antigenic peptide-induced transport of MHC class I molecules. With an emphasis on these major areas of research, we review recent developments on the molecular and biochemical mediators and events of MHC class I gene regulation.
主要组织相容性复合体（MHC）I类基因产物在向细胞免疫系统呈递外来抗原方面发挥着基本作用。人们已将大量注意力投向MHC I类基因表达的研究，以此作为理解MHC I类介导的免疫反应调控过程的一种手段。现已出现两个备受关注的领域，包括转录控制水平的调控以及抗原肽诱导的MHC I类分子转运。在重点关注这些主要研究领域的基础上，我们综述了MHC I类基因调控的分子和生化介质及相关事件的最新进展。
