Higashi O, Ishigaki W
Tohoku J Exp Med. 1977 Jan;121(1):41-6. doi: 10.1620/tjem.121.41.
Hydrogen peroxide can either induce or inhibit or enhance the platelet aggregation in vitro depending upon the experimental conditions. Vitamin E and vitamin E-nicotinate are found to be effective to inhibit, to some extent, the platelet aggregation induced by combined adenosine diphosphate (ADP) and hydrogen peroxide (H2O2), added simultaneously, to the platelet rich plasma (PRP). Vitamin E and vitamin E-nicotinate seemed, however, to be unable to prevent the reduction of platelet response to ADP, which was brought about by the pretreatment of PRP with H2O2 of a lower concentration.
在体外，根据实验条件的不同，过氧化氢既可以诱导、抑制或增强血小板聚集。研究发现，维生素E和维生素E烟酸酯在一定程度上可有效抑制同时添加到富血小板血浆（PRP）中的二磷酸腺苷（ADP）和过氧化氢（H₂O₂）所诱导的血小板聚集。然而，维生素E和维生素E烟酸酯似乎无法阻止低浓度H₂O₂预处理PRP所导致的血小板对ADP反应性的降低。
