Dahlin C, Linde A, Röckert H
Department of Oral Biochemistry, University of Göteborg, Sweden.
Scand J Plast Reconstr Surg Hand Surg. 1993;27(2):103-8. doi: 10.3109/02844319309079791.
Large bone defects often heal incompletely as a result of ingrowth of connective tissue. By using a mechanical hindrance, a porous expanded polytetrafluoroethylene (e-PTFE) membrane, it is possible to prevent fibroblasts and other soft connective tissue cells from entering the defect, thereby allowing osteogenesis to occur unhindered. As evidenced in several investigations, this osteopromotive membrane technique causes a strongly improved bone regeneration of well defined osseous lesions. Hyperbaric oxygen treatment has also been shown to accelerate bone healing. In this study the value of combining the two techniques was investigated. Through-and-through bone defects, 5 mm in diameter, were produced unilaterally in the angular region of the mandibles of adult rats (n = 60); the defects in half the number of animals were covered lingually and buccally with membranes. The animals were then divided into four groups: treatment with membrane alone, treatment with hyperbaric oxygen alone, combined treatment, and no treatment. Histological examination of the defects after 14 days showed that the combination of techniques had resulted in significant improvement in bone healing, compared with hyperbaric oxygen or the membrane technique alone. Synergistic effects can thus be achieved by the use of membranes and stimulatory factors for bone regeneration.
由于结缔组织长入，大的骨缺损常常愈合不完全。通过使用一种机械屏障——多孔性膨体聚四氟乙烯（e-PTFE）膜，能够防止成纤维细胞和其他软结缔组织细胞进入缺损区，从而使骨生成不受阻碍地发生。正如几项研究所证明的，这种促进骨生成的膜技术能显著改善明确界定的骨病变的骨再生情况。高压氧治疗也已被证明可加速骨愈合。在本研究中，对这两种技术联合使用的价值进行了调查。在成年大鼠（n = 60）下颌骨角区单侧制造直径5毫米的贯通性骨缺损；半数动物的缺损在舌侧和颊侧用膜覆盖。然后将动物分为四组：单独使用膜治疗、单独使用高压氧治疗、联合治疗和不治疗。14天后对缺损进行组织学检查显示，与单独使用高压氧或膜技术相比，联合技术使骨愈合有了显著改善。因此，通过使用膜和骨再生刺激因子可以实现协同效应。
