Schortinghuis Jurjen, Ruben Jan L, Raghoebar Gerry M, Stegenga Boudewijn
Department of Oral and Maxillofacial Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB, Groningen, The Netherlands.
Arch Oral Biol. 2004 May;49(5):413-20. doi: 10.1016/j.archoralbio.2003.12.006.
To decrease healing time of bone defects covered with osteoconductive membranes, an attempt was made to stimulate the osteoconductive process with therapeutic ultrasound. In 72 rats, a circular mandibular defect was created and covered on both sides with an e-PTFE membrane. A control group, an ultrasound treatment group and a placebo treatment group were studied. At 2 and 4 weeks, the osteoconduction was expressed as the percentage of defect closure using digitized microradiographs. At 2 weeks, there was no significant difference in the percentage of defect closure between the groups. At 4 weeks, there was significantly more bone defect closure in the placebo group (77.9%) as compared to the control group (59.3%). Membrane ultrasound attenuation measurements indicated that the membrane blocks most of the applied ultrasound. In conclusion, low intensity pulsed ultrasound does not appear to significantly stimulate osteoconduction into a bone defect in the rat mandible that is covered by an e-PTFE membrane.
为缩短骨传导膜覆盖的骨缺损愈合时间，研究人员尝试用治疗性超声刺激骨传导过程。在72只大鼠中制造了圆形下颌骨缺损，并在两侧覆盖e-PTFE膜。研究了一个对照组、一个超声治疗组和一个安慰剂治疗组。在第2周和第4周，使用数字化显微放射照片将骨传导表示为缺损闭合的百分比。在第2周时，各组之间缺损闭合的百分比没有显著差异。在第4周时，与对照组（59.3%）相比，安慰剂组（77.9%）的骨缺损闭合明显更多。膜超声衰减测量表明，该膜阻挡了大部分施加的超声。总之，低强度脉冲超声似乎不会显著刺激e-PTFE膜覆盖的大鼠下颌骨骨缺损处的骨传导。
