Metelitsyna I P, Petretskaia O S, Rodin S S, Andrianov S I
Ukr Biokhim Zh (1978). 1993 Jan-Feb;65(1):93-7.
The fibrinolytic properties of the preparations of plasmin (Pm), mixture of plasminogen and streptokinase (Pg+Sk), miniplasmin (m-Pm) and fibrinolysin have been investigated on the models of rabbit's hyphema. The action of preparations of Pm and Pg+Sk had approximately equal therapeutic index--the total destruction of clots proceeded for 12.0 days, that was 6.6 days less than in the control group. The therapeutic effect for m-Pm was 3.6 days. The dose of preparation of m-Pm, necessary for total destruction of clots, was 15-20% greater than for the same dose of Pg+Sk. The preparation of fibrinolysin, used in the same quantities of proteolytic activity, as Pg and m-Pg, (16 caseinolytic units per 1 injection) had no therapeutic effect.
在兔前房积血模型上研究了纤溶酶（Pm）制剂、纤溶酶原与链激酶混合物（Pg+Sk）、微型纤溶酶（m-Pm）和纤维蛋白溶酶制剂的纤溶特性。Pm和Pg+Sk制剂的作用具有大致相同的治疗指数——血栓完全溶解持续12.0天，比对照组少6.6天。m-Pm的治疗效果为3.6天。血栓完全溶解所需的m-Pm制剂剂量比相同剂量的Pg+Sk大15-20%。以与Pg和m-Pg相同的蛋白水解活性用量（每次注射16酪蛋白溶解单位）使用的纤维蛋白溶酶制剂没有治疗效果。
