Whitehair J G, Griffey S M, Olander H J, Vasseur P B, Naydan D
Veterinary Medical Teaching Hospital, University of California, Davis.
Vet Surg. 1993 Jul-Aug;22(4):255-9. doi: 10.1111/j.1532-950x.1993.tb00394.x.
The accuracy of diagnoses based on examination of frozen sections was determined by comparing the results to those obtained by examination of tissues prepared using conventional methods (formalin fixation, paraffin-embedded tissue). One hundred ninety-four specimens were examined using the frozen section technique; 37 were examined to confirm a tentative diagnosis or to document lymph node metastasis and the remainder were examined to diagnose an unknown pathologic process. Of the 194 specimens examined, an accurate, specific diagnosis was obtained in 161 (83%); in 19 (10%), the pathologic process was correctly identified, but a specific diagnosis was not obtained; and in 2 (1%) the diagnosis was deferred. The remaining 12 (6%) were incorrectly diagnosed by the frozen section technique. When the number of specimens in which a specific diagnosis was obtained was combined with the number of specimens in which the pathologic process was correctly identified, the overall accuracy rate of the frozen section technique was 93%. There was no difference in the accuracy of the frozen section technique based on the reason for submission of the sample, source of tissue submitted, or the type of pathologic process (i.e., inflammatory or neoplastic). Of the 12 incorrect diagnoses, 4 (33%) were because of sampling errors and 8 (67%) were caused by interpretation errors.(ABSTRACT TRUNCATED AT 250 WORDS)
通过将基于冰冻切片检查的诊断结果与使用传统方法（福尔马林固定、石蜡包埋组织）制备的组织检查结果进行比较，来确定基于冰冻切片检查的诊断准确性。使用冰冻切片技术检查了194个标本；其中37个用于确认初步诊断或记录淋巴结转移，其余用于诊断未知的病理过程。在检查的194个标本中，161个（83%）获得了准确、具体的诊断；19个（10%）正确识别了病理过程，但未获得具体诊断；2个（1%）诊断延迟。其余12个（6%）通过冰冻切片技术被误诊。当将获得具体诊断的标本数量与正确识别病理过程的标本数量相加时，冰冻切片技术的总体准确率为93%。基于送检样本的原因、送检组织的来源或病理过程的类型（即炎症或肿瘤），冰冻切片技术的准确性没有差异。在12个错误诊断中，4个（33%）是由于采样误差，8个（67%）是由解释误差引起的。（摘要截断于250字）
