Kubesová H, Zemanová J, Vorlícek J
II. interní klinika FNsP Brno Bohunice.
Vnitr Lek. 1993 May;39(5):437-44.
Aggressive chemotherapy used at present for the treatment of malignant haematological diseases leads to prolonged aplasia of the bone marrow with the possible development of fulminant infectious complications. Treatment of these complications must be started immediately when they are detected, i.e. as a rule without knowing the bacteriological finding at the time. The objective of the present work was to assess by analysis of 376 positive bacteriological findings from hospitalized patients with neutropenia and 141 findings of immunocompromised patients in their homes a combination of antibiotics for empirical treatment of infectious complications which developed during hospitalization or treatment at home.
目前用于治疗恶性血液病的强化化疗会导致骨髓长期再生障碍,并可能引发暴发性感染并发症。一旦发现这些并发症,必须立即开始治疗,也就是说,通常在当时并不知晓细菌学检查结果的情况下就开始治疗。本研究的目的是,通过分析376例住院中性粒细胞减少患者的阳性细菌学检查结果以及141例在家中的免疫功能低下患者的检查结果,评估用于经验性治疗住院期间或在家治疗期间发生的感染并发症的抗生素组合。