[蝙蝠葛碱对豚鼠心室乳头肌动作电位和慢内向电流的影响]
[Effects of dauricine on action potentials and slow inward currents of guinea pig ventricular papillary muscles].
作者信息
Li S N, Zhang K Y
机构信息
Department of Pharmacology, China Medical University, Shenyang.
出版信息
Zhongguo Yao Li Xue Bao. 1992 Nov;13(6):535-7.
Effects of dauricine (Dau) on the action potentials (AP), the slow action potentials (SAP), and the slow inward currents (Isi) of guinea pig ventricular papillary muscles were observed by means of intracellular microelectrode and single sucrose gap voltage clamp technique. In the early stage, Dau shortened action potential duration 100 (APD100) and effective refractory period (ERP) (ERP/APD < 1; P < 0.01), but did not affect APD20 and other parameters. In the late stage, Dau prolonged APD100, ERP, and APD20, significantly decreased action potential amplitude (APA), maximum velocity (Vmax), and overshot (OS) (ERP/APD > 1; P < 0.01), greatly diminished APA and OS of SAP induced by isoprenaline (P < 0.01), and remarkably inhibited Isi (P < 0.01). The results suggested that Dau exerted an inhibitory effect on Na+, Ca2+, and K+ channels.
采用细胞内微电极和单蔗糖间隙电压钳技术，观察了蝙蝠葛碱（Dau）对豚鼠心室乳头肌动作电位（AP）、慢动作电位（SAP）和慢内向电流（Isi）的影响。早期，Dau缩短动作电位时程100（APD100）和有效不应期（ERP）（ERP/APD<1；P<0.01），但不影响APD20及其他参数。后期，Dau延长APD100、ERP和APD20，显著降低动作电位幅度（APA）、最大速率（Vmax）和超射（OS）（ERP/APD>1；P<0.01），极大地减小异丙肾上腺素诱导的SAP的APA和OS（P<0.01），并显著抑制Isi（P<0.01）。结果提示，Dau对Na+、Ca2+和K+通道具有抑制作用。
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