大剂量阿糖胞苷神经毒性：急性期的磁共振成像表现
High-dose cytarabine neurotoxicity: MR findings during the acute phase.
作者信息
Vaughn D J, Jarvik J G, Hackney D, Peters S, Stadtmauer E A
机构信息
Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104.
出版信息
AJNR Am J Neuroradiol. 1993 Jul-Aug;14(4):1014-6.
Abstract
The authors report an acute cerebral and cerebellar syndrome in a patient treated with high-dose cytarabine. Diffuse high-intensity lesions in the central white matter on T2-weighted MR completely reversed with resolution of the clinical syndrome. Although the autopsy revealed cerebellar injury, the cerebral cortex was grossly and microscopically normal, consistent with a reversible process.
摘要
作者报告了1例接受大剂量阿糖胞苷治疗的患者出现急性脑和小脑综合征。T2加权磁共振成像显示中央白质弥漫性高强度病变，随着临床综合征的缓解完全逆转。尽管尸检显示小脑损伤，但大脑皮层在大体和显微镜下均正常，符合可逆性过程。
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