Jin A Y, Weaver D F
Department of Chemistry, Queen's University, Kingston, Ontario, Canada.
Biochem Biophys Res Commun. 1993 Aug 16;194(3):1117-23. doi: 10.1006/bbrc.1993.1937.
A computational model of the putative ion pore region of the HBK2 potassium channel was developed. Utilizing experimentally derived constraints, conformations corresponding to both the open and closed states of the ion pore were determined. Also, a conformational basis for the different sensitivites of the internal and external tetraethylammonium binding sites has been proposed. The model presented here suggests a role for other regions of the HBK2 protein in determining the ion pore conformation.
开发了一种HBK2钾通道假定离子孔区域的计算模型。利用实验得出的限制条件，确定了与离子孔开放和关闭状态相对应的构象。此外，还提出了内部和外部四乙铵结合位点不同敏感性的构象基础。此处提出的模型表明HBK2蛋白的其他区域在确定离子孔构象中发挥作用。
