Brewster B S, Jeal S, Strong P N
Neuromuscular Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
Biochem Biophys Res Commun. 1993 Aug 16;194(3):1256-60. doi: 10.1006/bbrc.1993.1958.
In order to identify the protein product of the recently characterised myotonic dystrophy gene, we have raised an antibody (DMAP1) to a peptide sequence of the predicted gene product. This antibody identifies a novel 52 kDa protein in a range of mouse tissues, and in addition a related 42 kDa protein in brain and heart. A second antibody raised to a different peptide from the same predicted sequence, also identifies the 52 kDa protein, which strongly implies that this 52 kDa protein is a major translation product of the myotonic dystrophy gene.
