Classen C U, Abele C, Schimatschek H F, Friedberg K D, Classen H G, Haubold W
Department of Pharmacology and Toxicology of Nutrition, University of Hohenheim, Fed. Rep. of Germany.
Arzneimittelforschung. 1993 Jun;43(6):672-5.
The enteral bioavailability of magnesium firmly bound to a fire-proof, inert SiO2-Al2O3 matrix (ground magnesia boats) was studied in magnesium-deficient albino Sprague-Dawley rats, with and without blocking gastric hydrochloric acid secretion with omeprazole. Magnesium was absorbed, although to a small degree, also at anacidity. Pronounced erythema, developing after only some days in hypomagnesemic hypercalcemic rats, are proposed as a non-invasive model for the screening of antiinflammatory substances. Using this model significant protective effects were proven for cromoglycate, polyenthylene glycol 400, and omeprazole; the latter, however, seems more likely to act via a magnesium-sparing mechanism.
在缺镁的白化斯普拉格-道利大鼠中，研究了牢固结合在防火惰性二氧化硅 - 氧化铝基质（研磨氧化镁舟皿）上的镁的肠内生物利用度，实验分使用奥美拉唑阻断胃盐酸分泌和未阻断胃盐酸分泌两组。即使在胃酸缺乏的情况下，镁也有少量吸收。低镁血症高钙血症大鼠仅在数天后出现的明显红斑，被提议作为筛选抗炎物质的非侵入性模型。使用该模型，已证实色甘酸盐、聚乙二醇400和奥美拉唑具有显著的保护作用；然而，后者似乎更可能通过保镁机制发挥作用。
