Parker M G
ICRF, Lincoln's Inn Fields, London, UK.
Curr Opin Cell Biol. 1993 Jun;5(3):499-504. doi: 10.1016/0955-0674(93)90016-j.
Steroid hormone receptors stimulate gene transcription by binding to DNA as homodimers, whereas many other members of the nuclear receptor family appear to function as heterodimers or as monomers. This is important for target gene recognition and, given that many of the receptors are expressed in multiple forms, generates many combinations of ligand-dependent transcription factors that regulate the expression of different genes in diverse pathways.
类固醇激素受体通过以同二聚体形式结合DNA来刺激基因转录，而核受体家族的许多其他成员似乎以异二聚体或单体形式发挥作用。这对于靶基因识别很重要，而且鉴于许多受体以多种形式表达，会产生许多依赖配体的转录因子组合，这些组合在不同途径中调节不同基因的表达。
