乳腺癌中的雌激素调节基因：pLIV1与内分泌治疗反应的关联。
Oestrogen-regulated genes in breast cancer: association of pLIV1 with response to endocrine therapy.
作者信息
McClelland R A, Manning D L, Gee J M, Willsher P, Robertson J F, Ellis I O, Blamey R W, Nicholson R I
机构信息
Tenovus Cancer Research Centre, University Hospital of Wales, Heath Park, Cardiff, UK.
出版信息
Br J Cancer. 1998 May;77(10):1653-6. doi: 10.1038/bjc.1998.271.
Abstract
Northern hybridization analyses of the oestrogen-inducible mRNAs pLIV1 and pS2 were compared with oestrogen receptor (ER) immunocytochemistry assessments in 40 untreated primary or early recurrent breast tumours. Significant associations were observed between pLIV1/ER (P < 0.03), pS2/ER (P < 0.001) and pLIV1/pS2 (P < 0.04) status. After disease recurrence, patients were treated with assessable courses of endocrine therapies. Positive pLIV1, pS2 and ER statuses in primary disease were consequently found to be predictive of endocrine responsiveness in the secondary lesions (P < 0.03, P < 0.02, P < 0.005 respectively). However, despite these associations, a number of pLIV1- and/or pS2-positive tumours failed to respond to therapy.
摘要
对40例未经治疗的原发性或早期复发性乳腺肿瘤进行雌激素诱导mRNA pLIV1和pS2的Northern杂交分析，并与雌激素受体（ER）免疫细胞化学评估结果进行比较。观察到pLIV1/ER（P < 0.03）、pS2/ER（P < 0.001）和pLIV1/pS2（P < 0.04）状态之间存在显著关联。疾病复发后，患者接受了可评估疗程的内分泌治疗。结果发现，原发性疾病中pLIV1、pS2和ER阳性状态可预测继发性病变的内分泌反应性（分别为P < 0.03、P < 0.02、P < 0.005）。然而，尽管存在这些关联，仍有一些pLIV1和/或pS2阳性肿瘤对治疗无反应。
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