McLeay G F, Steward W P
Beatson Oncology Centre, Western Infirmary, Glasgow, U.K.
Ann Oncol. 1993 Jun;4(6):509-14. doi: 10.1093/oxfordjournals.annonc.a058563.
The management of our patient was similar to that of many patients with soft tissue sarcomas. His primary care was in a General Hospital where the surgeon had no specialist experience of these tumours and did not anticipate such a diagnosis. As a result the diagnostic procedure was inappropriate and compromised the chances of success of further more radical conservative surgery. Radiotherapy was unable to prevent local recurrence and amputation became necessary. Pulmonary metastases developed and were resected but within a short space of time extensive inoperable metastases recurred. Although these responded to chemotherapy, the response duration was short and the patient died soon afterwards. The major lessons to be learned are the need to have a high index of suspicion about a possible neoplastic cause of increasing soft tissue swellings and to refer patients for biopsy to a specialist centre where there is experience of all aspects of the management of these rare but potentially curable malignancies.
我们这位患者的治疗过程与许多软组织肉瘤患者相似。他最初在一家综合医院接受治疗,那里的外科医生没有这些肿瘤的专科经验,也没有预见到这样的诊断结果。因此,诊断程序不恰当,损害了进一步进行更彻底保守手术成功的机会。放疗无法防止局部复发,截肢成为必要手段。肺部转移瘤出现并被切除,但在短时间内又复发了广泛的无法手术切除的转移瘤。尽管这些转移瘤对化疗有反应,但反应持续时间很短,患者随后不久就去世了。需要吸取的主要教训是,对于软组织肿胀增加可能由肿瘤引起要有高度的怀疑指数,并将患者转诊至有这些罕见但潜在可治愈恶性肿瘤各方面管理经验的专科中心进行活检。