Boudghène F, Anidjar S, Allaire E, Osborne-Pellegrin M, Bigot J M, Michel J B
Vascular and Interventional Unit, Hopital Tenon, Paris, France.
J Vasc Interv Radiol. 1993 Jul-Aug;4(4):497-504. doi: 10.1016/s1051-0443(93)71905-3.
A new model of aortic aneurysm was developed in 12 beagles to study the feasibility of endoluminal exclusion of aortic aneurysms.
After preliminary experiments in four dogs, aneurysms were induced by infusing elastase into an isolated segment of the abdominal aorta in eight dogs. To create aortic endoprostheses, a Palmaz stent was sutured onto each end of an ultrathin Dacron tube. Endoprosthesis placement was performed under fluoroscopic and intravascular ultrasonographic (US) guidance. The endoprostheses were introduced via a femoral arteriotomy, through a 12-F sheath positioned in the aorta, and then were expanded on an angioplasty catheter.
Intravascular US and aortography showed aneurysms in the elastase-perfused area in the eight animals and demonstrated the exclusion of the aneurysm by the endoprostheses in six cases. Intravascular US was more accurate than aortography in demonstrating two cases of endoprosthesis dysfunction. Aneurysm formation was proportional to the loss of elastic tissue observed at histologic examination of the elastase-infused area. Macro- and microscopic examinations confirmed thrombosis of the excluded part of the aneurysm and patency of all grafts.
This model and intravascular US appear helpful in exploring the feasibility of endovascular treatment of abdominal aortic aneurysm.
在12只比格犬身上建立一种新的主动脉瘤模型，以研究腔内隔绝治疗主动脉瘤的可行性。
在4只犬身上进行初步实验后，对8只犬的腹主动脉孤立节段注入弹性蛋白酶以诱发动脉瘤。为制作主动脉内支架，将一个帕尔马兹支架缝合到一根超薄涤纶管的两端。在荧光透视和血管内超声（US）引导下进行内支架置入。通过股动脉切开，经置于主动脉内的12F鞘管引入内支架，然后在血管成形术导管上进行扩张。
血管内超声和主动脉造影显示8只动物弹性蛋白酶灌注区域存在动脉瘤，6例显示内支架隔绝了动脉瘤。在显示2例内支架功能障碍方面，血管内超声比主动脉造影更准确。动脉瘤形成与弹性蛋白酶灌注区域组织学检查中观察到的弹性组织丧失成正比。大体和显微镜检查证实动脉瘤被隔绝部分形成血栓，所有移植物通畅。
该模型和血管内超声似乎有助于探索腹主动脉瘤血管内治疗的可行性。
