Boussinesq M, Chippaux J P, Ernould J C, Prod'Hon J, Quillévéré D
Antenne ORSTOM auprès du Centre Pasteur du Cameroun, Yaoundé.
Bull Soc Pathol Exot. 1993;86(2):112-5.
321 adults living in an hyperendemic onchocerciasis focus in North-Cameroon who received a first dose of ivermectin (150 micrograms/kg) in 1987 and a total of three, four or five doses from 1987 to 1991 were parasitologically examined in 1992. The prevalence of skin microfilariae (PMf) and the geometric mean microfilarial load (GMMf) were respectively reduced by 33 and 97% from the initial values in the group of subjects who received five treatments. In 1992, the PMf and the GMMf were not significantly different in the groups which received three, four or five doses of ivermectin. It is not necessary to achieve an important drug coverage to maintain a tolerable level of infestation in the community.
1992年，对居住在喀麦隆北部盘尾丝虫病高度流行区的321名成年人进行了寄生虫学检查。这些成年人在1987年接受了第一剂伊维菌素（150微克/千克），并在1987年至1991年间总共接受了三剂、四剂或五剂伊维菌素。接受五次治疗的受试者组中，皮肤微丝蚴（PMf）的患病率和微丝蚴几何平均负荷（GMMf）分别比初始值降低了33%和97%。1992年，接受三剂、四剂或五剂伊维菌素的组中，PMf和GMMf没有显著差异。在社区中，不必实现很高的药物覆盖率就能维持可耐受的感染水平。
