Javorka K, Plank L, Adamicová K, Kulisek V
Ustav fyziológie LFUK, Martin, Slovakia.
Bratisl Lek Listy. 1993 Feb;94(2):94-8.
In anesthetized rabbits, the occurrence of histopathological changes was studied above below and the level of the endotracheal tube opening after one-hour high-frequency jet ventilation (f = 150.min-1,Pin = 70-90 kPa, Ti = 0.5) with nonhumidified air and oxygen mixture (FiO2 = 0.6). The findings were compared with those obtained in intact rabbits and in rabbits which were inhaling nonhumidified air from the environment spontaneously via the endotracheal tube. Mechanical obstruction of the airways by mucus or necrosis of the mucous membrane was not observed. The major histopathological changes characteristic of inflammation and mechanical damage of the mucosa were recorded above the opening of the endotracheal tube. Towards the main bronchi the degree of the injury was decreasing. (Tab. 2, Fig. 2, Ref. 11.)
在麻醉兔中,研究了在使用未湿化的空气和氧气混合物(FiO2 = 0.6)进行1小时高频喷射通气(f = 150次/分钟,Pin = 70 - 90 kPa,Ti = 0.5)后,气管导管开口水平上下的组织病理学变化。将这些结果与完整兔以及通过气管导管自发从环境中吸入未湿化空气的兔所获得的结果进行比较。未观察到气道被黏液机械性阻塞或黏膜坏死。气管导管开口上方记录到了黏膜炎症和机械性损伤的主要组织病理学变化特征。朝向主支气管,损伤程度逐渐减轻。(表2,图2,参考文献11)