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[短期高频喷射通气会损害气管支气管黏膜吗?]

[Does short-term high-frequency jet ventilation damage the tracheobronchial mucosa?].

作者信息

Javorka K, Plank L, Adamicová K, Kulisek V

机构信息

Ustav fyziológie LFUK, Martin, Slovakia.

出版信息

Bratisl Lek Listy. 1993 Feb;94(2):94-8.

PMID:8353749
Abstract

In anesthetized rabbits, the occurrence of histopathological changes was studied above below and the level of the endotracheal tube opening after one-hour high-frequency jet ventilation (f = 150.min-1,Pin = 70-90 kPa, Ti = 0.5) with nonhumidified air and oxygen mixture (FiO2 = 0.6). The findings were compared with those obtained in intact rabbits and in rabbits which were inhaling nonhumidified air from the environment spontaneously via the endotracheal tube. Mechanical obstruction of the airways by mucus or necrosis of the mucous membrane was not observed. The major histopathological changes characteristic of inflammation and mechanical damage of the mucosa were recorded above the opening of the endotracheal tube. Towards the main bronchi the degree of the injury was decreasing. (Tab. 2, Fig. 2, Ref. 11.)

摘要

在麻醉兔中,研究了在使用未湿化的空气和氧气混合物(FiO2 = 0.6)进行1小时高频喷射通气(f = 150次/分钟,Pin = 70 - 90 kPa,Ti = 0.5)后,气管导管开口水平上下的组织病理学变化。将这些结果与完整兔以及通过气管导管自发从环境中吸入未湿化空气的兔所获得的结果进行比较。未观察到气道被黏液机械性阻塞或黏膜坏死。气管导管开口上方记录到了黏膜炎症和机械性损伤的主要组织病理学变化特征。朝向主支气管,损伤程度逐渐减轻。(表2,图2,参考文献11)

相似文献

1
[Does short-term high-frequency jet ventilation damage the tracheobronchial mucosa?].[短期高频喷射通气会损害气管支气管黏膜吗?]
Bratisl Lek Listy. 1993 Feb;94(2):94-8.
2
Bronchofiberscopic observations of the tracheobronchial tree during intubation.插管期间气管支气管树的纤维支气管镜观察。
Am Rev Respir Dis. 1972 May;105(5):747-55. doi: 10.1164/arrd.1972.105.5.747.
3
Comparison of airway pathologic lesions after high-frequency jet or conventional ventilation.
Am J Dis Child. 1989 Feb;143(2):228-32. doi: 10.1001/archpedi.1989.02150140122033.
4
Bronchoscopic findings in infants treated with high-frequency jet ventilation versus conventional ventilation.高频喷射通气与传统通气治疗的婴儿的支气管镜检查结果
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5
Pathogenesis and prevention of tracheobronchial damage with suction procedures.吸引操作导致气管支气管损伤的发病机制与预防
Chest. 1973 Sep;64(3):284-90. doi: 10.1378/chest.64.3.284.
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Crit Care Med. 2003 Mar;31(3):916-23. doi: 10.1097/01.CCM.0000053524.86705.05.
7
Different humidification systems for high-frequency jet ventilation.用于高频喷射通气的不同加湿系统。
Crit Care Med. 1984 Sep;12(9):815-9. doi: 10.1097/00003246-198409000-00031.
8
Tracheobronchial and pulmonary histopathology following conventional and high-frequency jet ventilation.
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9
[Pathomorphology of various changes in trachea and bronchi during long term mechanical ventilation].[长期机械通气期间气管和支气管各种变化的病理形态学]
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Crit Care Med. 1984 Sep;12(9):829-32. doi: 10.1097/00003246-198409000-00035.