Glasa J, Turecký L, Holomán J
Subkatedra klinickej farmakológie ILF v Bratislave, Slovakia.
Bratisl Lek Listy. 1993 Mar;94(3):139-45.
In a simple uncontrolled toxicological study 27 workers of an anesthesiology-resuscitation department of a hospital type III were examined. Besides detailed clinical examination, determination of basic hematological and biochemical parameters as well as ultrasonography, also selected parameters of proteosynthetic function of the liver, some so-called proteins of the acute phase and the biological half-life of antipyrine were established in the workers under study. The occurrence of pathological findings in the picture of the examinations performed was related to long-term professional exposure to halothane over the period of one year before the examination. With regard to the possibility of chronic hepatotoxic damage, appropriate attention should be paid to workers of anesthesiology-resuscitation departments, concerning particularly entrance medical examinations and regular screening and follow-up of their health condition, including check-ups hepatic parameters. (Tab. 4, Ref. 23.)
在一项简单的非对照毒理学研究中，对一家三级医院麻醉复苏科的27名工作人员进行了检查。除了详细的临床检查、基本血液学和生化参数测定以及超声检查外，还对研究对象的肝脏蛋白质合成功能的选定参数、一些所谓的急性期蛋白以及安替比林的生物半衰期进行了测定。所进行的检查结果中病理发现的出现与检查前一年长期职业性接触氟烷有关。关于慢性肝毒性损害的可能性，应特别关注麻醉复苏科工作人员，尤其要关注入职体检以及对他们健康状况的定期筛查和随访，包括肝脏参数检查。（表4，参考文献23）
