Gerli R, Agea E, Muscat C, Bertotto A, Ercolani R, Bistoni O, Bini P, Spinozzi F, Venanzi F
Institute of Internal Medicine, University of Perugia, Italy.
Clin Exp Rheumatol. 1993 May-Jun;11(3):295-9.
High percentages of gamma/delta+ T cells in the peripheral blood of a subgroup of patients with primary Sjögren's syndrome (SS) were found. This allowed us to purify and analyze them without their being previously expanded in vitro, and to investigate, therefore, the role of these cells in the pathological immune response which characterizes such systemic autoimmune disorders. The results showed poor proliferation of patient gamma/delta+ T cells in response to anti-CD3, due not to macrophage-dependent suppression but to defective interleukin 2 (IL-2) synthesis. Despite the defective proliferation patient gamma/delta+ cells, unlike those of the normal controls, provided a helper effect in inducing B cells to secrete immunoglobulins (Ig), particularly when they were preincubated with IL-2. The relative increase in a gamma/delta+ T cell subset which, although it secretes low levels of IL-2, is able to provide help for B-cell Ig synthesis, suggests that this T-cell subpopulation may be functional in vivo and may be involved in the pathological immune response encountered in pSS.
在原发性干燥综合征（SS）患者亚组的外周血中发现了高比例的γ/δ⁺ T细胞。这使我们能够在不事先进行体外扩增的情况下对其进行纯化和分析，从而研究这些细胞在这种系统性自身免疫性疾病所特有的病理性免疫反应中的作用。结果显示，患者γ/δ⁺ T细胞对抗CD3的增殖反应较差，这并非由于巨噬细胞依赖性抑制，而是由于白细胞介素2（IL-2）合成缺陷。尽管患者γ/δ⁺细胞增殖存在缺陷，但与正常对照不同的是，它们在诱导B细胞分泌免疫球蛋白（Ig）方面具有辅助作用，特别是当它们与IL-2预孵育时。一个γ/δ⁺ T细胞亚群相对增加，尽管它分泌低水平的IL-2，但能够为B细胞Ig合成提供帮助，这表明该T细胞亚群可能在体内发挥功能，并可能参与原发性干燥综合征中遇到的病理性免疫反应。
