老年受试者安替比林半衰期的可重复性

Reproducibility of antipyrine half-lives in elderly subjects.

作者信息

Vesell E S, DeAngelo T M, Katz I R

机构信息

Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey 17033.

出版信息

Clin Pharmacol Ther. 1993 Aug;54(2):150-7. doi: 10.1038/clpt.1993.126.

DOI:10.1038/clpt.1993.126

PMID:8354024

Abstract

Antipyrine half-life determined on three to five separate occasions over a period ranging from 3 weeks to 1 year was highly reproducible in each of 20 elderly subjects (12 women and 8 men; mean age, 83 years). The mean within-subject coefficient of variation for antipyrine half-life was 9.6%, whereas the between-subject coefficient of variation was 33.3%. These findings indicate high reproducibility of individual rates of drug metabolism in medically stable elderly subjects.

摘要

在20名老年受试者（12名女性和8名男性；平均年龄83岁）中，在3周至1年的时间段内，分三到五次测定的安替比林半衰期具有高度可重复性。安替比林半衰期的受试者内变异系数平均值为9.6%，而受试者间变异系数为33.3%。这些发现表明，在医学状况稳定的老年受试者中，药物代谢个体速率具有高度可重复性。