Uhlig H, Damrau J, Skölziger R
Z Gesamte Hyg. 1989 Feb;35(2):82-4.
The antipyrine half-life is a reliable index of biotransformation capacity of the liver. The half-lives were estimated in 137 subjects; the result was a logarithmic normal distribution of these parameters. Therefore our patients were subdivided into groups of so-called fast, intermediate and slow metabolisers (fast: t50 less than 7.6 h and slow: t50 greater than 14.9 h). Under conditions given here the intraindividual coefficient of variation was about 11.5%. The antipyrine elimination curves were calculated by a computer programme and the values were analysed statistically.
安替比林半衰期是肝脏生物转化能力的可靠指标。在137名受试者中估计了半衰期；这些参数呈对数正态分布。因此，我们将患者分为所谓的快代谢者、中代谢者和慢代谢者组（快代谢者：t50小于7.6小时，慢代谢者：t50大于14.9小时）。在此给出的条件下，个体内变异系数约为11.5%。通过计算机程序计算安替比林消除曲线，并对这些值进行统计学分析。
