Kuse H, Okaniwa A
Safety Research Laboratory, Tanabe Seiyaku Co. Ltd., Osaka, Japan.
Jikken Dobutsu. 1993 Jul;42(3):377-82. doi: 10.1538/expanim1978.42.3_377.
Postnatal development of the auditory brainstem response (ABR) in beagles was studied by repeated ABR recordings from birth to 16 weeks of age. In ABR recording, waves I, II and III appeared at the same time 13 to 17 days of age, while wave IV during 13 to 20 days of age and wave V during 20 to 35 days of age, respectively. The latencies of waves II, III and IV became close to the control level at 6 weeks of age, whereas wave I had a similar latency to the control at 3 weeks of age. The latency of wave V became close to the control level at 8 weeks of age. I-III interpeak latency stabilized at 4 weeks of age, however, I-V and III-V interpeak latencies stabilized during 8 to 10 weeks of age. There was a marked individual difference in amplitude of ABR components in beagles. Wave I amplitude reached the plateau level at 3 weeks of age, and wave II, III and IV at 6 weeks of age. No further development in ABR was observed on and after 10 weeks of age. It may be concluded, from electrophysiological point of view, that the peripheral auditory pathway matures at 3 weeks of age and the auditory rely system in brainstem at 10 weeks of age in beagles.
通过从出生到16周龄反复记录比格犬的听觉脑干反应（ABR），研究了其产后发育情况。在ABR记录中，I、II和III波在13至17日龄时同时出现，而IV波在13至20日龄出现，V波在20至35日龄出现。II、III和IV波的潜伏期在6周龄时接近对照水平，而I波在3周龄时潜伏期与对照相似。V波潜伏期在8周龄时接近对照水平。I-III峰间潜伏期在4周龄时稳定，然而，I-V和III-V峰间潜伏期在8至10周龄时稳定。比格犬ABR各波的波幅存在明显的个体差异。I波波幅在3周龄时达到平台期水平，II、III和IV波在6周龄时达到平台期水平。在10周龄及之后未观察到ABR有进一步发育。从电生理学角度可以得出结论，比格犬的外周听觉通路在3周龄时成熟，脑干听觉传导系统在10周龄时成熟。
