Steinert H C, Huch Böni R A, Buck A, Böni R, Berthold T, Marincek B, Burg G, von Schulthess G K
Department of Medical Radiology, University Hospital, Zürich, Switzerland.
Radiology. 1995 Jun;195(3):705-9. doi: 10.1148/radiology.195.3.7753998.
To evaluate whole-body positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in the detection of metastasis from melanoma.
Whole-body PET was performed in 33 patients with either known metastatic or newly diagnosed melanoma. Patients with suspected metastases also underwent computed tomography, magnetic resonance imaging, or both. Diagnoses were confirmed with histologic examination or with at least one imaging modality in addition to PET. Blinded interpretations of PET scans were performed.
Forty of 53 lesions evaluated proved to be melanoma metastases. Whole-body PET correctly depicted 37 sites of metastases. Three cutaneous metastases (< 3 mm) were missed. PET correctly excluded malignancy in 10 cases where suspicious lesions were found with conventional cross-sectional imaging modalities but later ruled out with fine-needle biopsy. In six patients, PET depicted new metastases. The sensitivity for the detection of malignant lesions was 92%; the specificity for reading the PET images without clinical information was 77% and with clinical information was 100%.
These results suggest that whole-body FDG PET is an effective imaging modality to screen for metastases from malignant melanoma.
评估采用2-[氟-18]-氟-2-脱氧-D-葡萄糖（FDG）的全身正电子发射断层扫描（PET）在检测黑色素瘤转移灶中的应用。
对33例已知有转移或新诊断的黑色素瘤患者进行全身PET检查。疑似转移的患者还接受了计算机断层扫描、磁共振成像或两者检查。诊断通过组织学检查或除PET外至少一种成像方式得以证实。对PET扫描进行了盲法解读。
评估的53个病灶中有40个被证实为黑色素瘤转移灶。全身PET正确显示了37个转移部位。遗漏了3个皮肤转移灶（<3毫米）。在10例通过传统横断面成像方式发现可疑病灶但后来经细针活检排除恶性的病例中，PET正确排除了恶性病变。在6例患者中，PET显示出了新的转移灶.检测恶性病灶时的敏感性为92%；在无临床信息时解读PET图像的特异性为77%，有临床信息时为100%。
这些结果表明，全身FDG PET是筛查恶性黑色素瘤转移灶的一种有效成像方式。
