Petri W H, Wilson T M
Department of Oral and Maxillofacial Surgery, Louisiana State University Medical Center, New Orleans 70119-2799.
J Oral Maxillofac Surg. 1993 Sep;51(9):982-5; discussion 986. doi: 10.1016/s0278-2391(10)80039-4.
Antibiotic-supplemented bone allograft (ASBA) was originally developed for treatment of combat-acquired, avulsive defects of the oral and maxillofacial skeleton. Earlier findings in experimental wound models showed that ASBA resulted in significantly improved wound repair of infected osseous defects when compared with conventional treatment. In this study, ASBA was evaluated in paired, comparable, mandibular third molar sockets and compared with the findings following conventional surgical removal. The results of this assessment showed that wound healing was significantly improved with the use of ASBA. Evidence produced by this clinical evaluation of ASBA suggests its potential use for other surgical bone defects when grafting is precluded by the risk of infection as a result of contamination by oral flora.
抗生素补充骨移植（ASBA）最初是为治疗战斗中获得的口腔颌面部骨骼撕脱性缺损而开发的。早期在实验性伤口模型中的研究结果表明，与传统治疗相比，ASBA能显著改善感染性骨缺损的伤口修复。在本研究中，对配对的、具有可比性的下颌第三磨牙牙槽窝进行了ASBA评估，并与传统手术拔除后的结果进行了比较。该评估结果表明，使用ASBA可显著改善伤口愈合。对ASBA的这一临床评估所产生的证据表明，当因口腔菌群污染导致感染风险而无法进行移植时，ASBA在其他手术性骨缺损中具有潜在的应用价值。
