Chan G M
Department Pediatrics, University of Utah Health Science Center, Salt lake City 84132.
J Pediatr. 1993 Sep;123(3):439-43. doi: 10.1016/s0022-3476(05)81754-8.
The objective of this study was to determine whether the growth and bone mineral status of discharged preterm infants fed human milk differed from those of infants fed one of three different formulas varying in calcium content (545 mg/L, 660 mg/L, or 1290 mg/L). A randomized, blinded study was conducted for 16 weeks after discharge in 16 human milk-fed and 43 formula-fed infants. All formula-fed infants received one of the three study formulas from discharge to 8 weeks afterward, and the standard formula, which contained 545 mg/L calcium, from 8 to 16 weeks. The human milk-fed infants gained weight more slowly than the formula-fed infants. The human milk-fed infants also had lower gains in length and higher serum alkaline phosphatase values than the formula-fed infants. The infants who received the formula containing the highest calcium concentration (1290 mg/L) had greater bone mineral density during the first 8 weeks of the study. We conclude that preterm infants recently discharged from the hospital may benefit from higher calcium intake than is provided by either human milk or standard term formula.
本研究的目的是确定喂养母乳的出院早产儿的生长和骨矿物质状况是否与喂养三种不同钙含量（545毫克/升、660毫克/升或1290毫克/升）配方奶之一的婴儿不同。对16名母乳喂养和43名配方奶喂养的婴儿出院后进行了为期16周的随机、盲法研究。所有配方奶喂养的婴儿从出院到8周接受三种研究配方奶之一，从8周到16周接受含545毫克/升钙的标准配方奶。母乳喂养的婴儿体重增加比配方奶喂养的婴儿慢。母乳喂养的婴儿身长增加也比配方奶喂养的婴儿少，血清碱性磷酸酶值更高。在研究的前8周，接受钙浓度最高（1290毫克/升）配方奶的婴儿骨密度更高。我们得出结论，刚出院的早产儿可能从比母乳或标准足月配方奶提供量更高的钙摄入量中获益。
