用于囊性纤维化的胎粪检测试纸筛查

Test strip meconium screening for cystic fibrosis.

作者信息

Bruns W T, Connell T R, Lacey J A, Whisler K E

出版信息

Am J Dis Child. 1977 Jan;131(1):71-3. doi: 10.1001/archpedi.1977.02120140073013.

DOI:10.1001/archpedi.1977.02120140073013

Abstract

The Boehringer-Mannheim Corporation (BMC) strip test is extremely reliable in indicating an albumin content above 20 mg/gm of dried meconium. All infants born during one year in 14 Milwaukee area hospitals were tested. Of 16,224 newborns, two were diagnosed correctly as suffering from cystic fibrosis and two were missed. False-positive tests were obtained in 0.9% of infants (prematurity, melena, gastroschisis, and intrauterine infection). The strip test is, at present, the best available but not the perfect screening method for cystic fibrosis.

摘要

勃林格殷格翰公司（BMC）试纸检测在检测胎粪干重中白蛋白含量高于20mg/g时极为可靠。对密尔沃基地区14家医院一年内出生的所有婴儿进行了检测。在16224名新生儿中，有两名被正确诊断为患有囊性纤维化，另外两名漏诊。0.9%的婴儿（早产、黑便、腹裂和宫内感染）出现假阳性检测结果。目前，试纸检测是囊性纤维化现有的最佳检测方法，但并非完美的筛查方法。