Glueck C J, Tsang R C, Fallat R W, Mellies M J
Am J Dis Child. 1977 Feb;131(2):162-6. doi: 10.1001/archpedi.1977.02120150044009.
Effects of a cholesterol- and saturate-poor, polyunsaturate-rich diet on plasma total and low-density lipoprotein (LDL) cholesterol levels were assessed in 23 children between the ages of 2 and 7 who were heterozygous for well-documented familial hypercholesterolemia. Sixteen of the 23 children, whose mean age at inception of diet was 4.8 years, sustained 10.5% and 11.3% reductions in total and LDL cholesterol levels after six months on diet (P less than .001). Total and LDL cholesterol levels were normal in only one of these children after six months. After one year on diet, three of 11 children had normal values for total and LDL cholesterol. Six of the 23 children, all 2 years old, had been previously maintained on low-cholesterol diets since age 1 or earlier, and three had normal cholesterol levels at the initial sampling for this study. After one year of follow-up in the study, the plasma cholesterol level was normal in five of these six children. Dietary therapy in the 2- to 7-year-old children heterozygous for familial hypercholesterolemia provided mean overall reduction of total and Ldl cholesterol levels between 6% and 15%, and appeared to be the most effective when instituted in children at ages 1 or 2.
对23名2至7岁的杂合子家族性高胆固醇血症患儿，评估了低胆固醇和饱和脂肪、高多不饱和脂肪饮食对血浆总胆固醇和低密度脂蛋白（LDL）胆固醇水平的影响。23名患儿中，16名患儿开始饮食干预时的平均年龄为4.8岁，饮食干预6个月后，总胆固醇和LDL胆固醇水平分别降低了10.5%和11.3%（P<0.001）。6个月后，这些患儿中只有1名患儿的总胆固醇和LDL胆固醇水平正常。饮食干预1年后，11名患儿中有3名患儿的总胆固醇和LDL胆固醇值正常。23名患儿中有6名患儿，均为2岁，自1岁或更早开始一直维持低胆固醇饮食，其中3名患儿在本研究初始采样时胆固醇水平正常。经过1年的随访，这6名患儿中有5名患儿的血浆胆固醇水平正常。对2至7岁的家族性高胆固醇血症杂合子患儿进行饮食治疗，可使总胆固醇和LDL胆固醇水平平均总体降低6%至15%，且在1岁或2岁的患儿中开始治疗时似乎最为有效。
