Hiatt R B, Goodman I, Sandler B, Cheskin H
Am J Dig Dis. 1977 Feb;22(2):108-12. doi: 10.1007/BF01072951.
Coherin, a substance isolated from the bovine posterior pituitary gland exists as a complex which is dissociated to yield at least two distinct enteroactive polypeptides, coherin A and B, and a third having little or no activity, coherin C. The effects of intravenous injection of nondissociated coherin (coherin G-25), coherin A, coherin B, vasopressin, and normal saline solution on the BER of the ileal Biebl loop in fasting dogs were investigated. The BER patterns in preinjection and postinjection periods were compared for each substance. The effects on the BER of each substance were compared with that of saline. Monopolar recordings were made from six electrodes 5 mm apart inserted into the ileal musculature of the Biebl loops. Coherin A significantly altered the electroenterograms in two ways. It increased phase locking in the ileal BER of the fasting dog and increased the amount of caudad BER propagation.
凝聚素是一种从牛脑垂体后叶分离出的物质，它以复合物形式存在，该复合物解离后可产生至少两种不同的具有肠活性的多肽，即凝聚素A和B，以及第三种活性很小或无活性的凝聚素C。研究了静脉注射未解离的凝聚素（凝聚素G - 25）、凝聚素A、凝聚素B、血管加压素和生理盐水对禁食犬回肠Biebl袢基础电节律（BER）的影响。比较了每种物质注射前和注射后阶段的BER模式。将每种物质对BER的影响与生理盐水的影响进行比较。在插入Biebl袢回肠肌肉组织的相距5毫米的六个电极上进行单极记录。凝聚素A以两种方式显著改变了肠电图。它增加了禁食犬回肠BER中的锁相，并增加了尾侧BER的传播量。
