Hiatt R B, Goodman I
Am J Surg. 1979 Jan;137(1):82-6. doi: 10.1016/0002-9610(79)90015-1.
Coherin, a peptide isolated from the bovine neurohypophysis, has been shown to be an effective therapeutic agent in post-gastric surgery physiologic obstruction and regional ileitis. Of twenty-four patients with post-gastric surgery physiologic obstruction, coherin relieved symptoms in twenty-three, a 96 per cent efficacy rate. The efficacy of coherin with ileitis was based on the fact that ten of twenty-seven patients treated have required coherin on a continuing basis to stay functional. These patients have requested coherin treatment for an average of five years each, and have each on multiple occasions tried to discontinue coherin treatment with prompt return of symptoms and cessation of symptoms when coherin was reinstituted. All of the ileitis patients had previously failed to respond to standard and usual medical treatment.
相干素是一种从牛神经垂体中分离出的肽，已被证明是治疗胃切除术后生理性梗阻和局限性回肠炎的有效药物。在24例胃切除术后生理性梗阻患者中，相干素使23例患者症状缓解，有效率为96%。相干素对回肠炎的疗效基于以下事实：27例接受治疗的患者中有10例需要持续使用相干素以维持正常功能。这些患者平均每人请求使用相干素治疗5年，并且每人都多次尝试停止使用相干素治疗，但症状迅速复发，而重新使用相干素后症状又消失。所有回肠炎患者此前对标准和常规药物治疗均无反应。
