Woussen-Colle M C, De Graef J
Am J Dig Dis. 1977 Feb;22(2):132-6. doi: 10.1007/BF01072956.
The effect of graded doses of synthetic human gastrin and pentagastrin on gastric secretion from the innervated and denervated stomach was measured in dogs. The circulating levels of gastrin during the infusion of this hormone were also estimated. The increase in gastrinemia for a fixed dose of exogenous gastrin differed from dog to dog. The dose for half-maximal response to gastrin was negatively correlated with the observed increase in serum gastrin. This suggests that the disposal rate of gastrin influences the calculated sensitivity of the parietal cells to this hormone. In the gastric fistula and in the pouch, maximal acid responses for gastrin and pentagastrin were linearly correlated, but doses for half maximal responses were not. This indicates that step-dose infusion of pentagastrin may be used to estimate the maximal acid response to gastrin, but it is not proven that such a test is useful to estimate the sensitivity of the parietal cells to gastrin in individual dogs.
在犬类身上测量了不同剂量的合成人胃泌素和五肽胃泌素对有神经支配和去神经支配的胃的胃液分泌的影响。同时还估算了在输注这种激素期间胃泌素的循环水平。对于固定剂量的外源性胃泌素，不同犬只的胃泌素血症升高情况有所不同。胃泌素半数最大反应剂量与观察到的血清胃泌素升高呈负相关。这表明胃泌素的清除率会影响计算得出的壁细胞对这种激素的敏感性。在胃瘘和胃小囊中，胃泌素和五肽胃泌素的最大酸反应呈线性相关，但半数最大反应剂量却并非如此。这表明五肽胃泌素的逐步剂量输注可用于估算对胃泌素的最大酸反应，但尚未证实这种检测方法对于估算个体犬只壁细胞对胃泌素的敏感性是否有用。
