Ward F E, Biegel A A
Am J Hum Genet. 1976 Jan;28(1):1-8.
The polymorphic HL-A histocompatibility system has been studied in North American black families. The family studies show that haplotype frequencies differ between black and white populations. Seven haplotypes (W28,W5; W28,W17; W28, undefined four; W23,W5; W19,W5; undefined LA,W5; and undefined LA, undefined four) were significantly more frequent in blacks than whites, while haplotypes 1,8 and 3,7 were significantly less frequent. Some of these differences may be accounted for by differences in gene frequencies between the two groups; other differences may be explained by linkage disequilibrium in the white population. No significant linkage disequilibrium between the LA and FOUR loci was found in the black population.
多态性HL - A组织相容性系统已在北美黑人家庭中进行了研究。家族研究表明，黑人和白人种群之间的单倍型频率存在差异。七种单倍型（W28,W5；W28,W17；W28，未定义的四种；W23,W5；W19,W5；未定义的LA,W5；以及未定义的LA，未定义的四种）在黑人中比在白人中更为常见，而单倍型1,8和3,7则明显较少见。这些差异中的一些可能是由于两组之间基因频率的差异；其他差异可能是由白人种群中的连锁不平衡所解释。在黑人种群中未发现LA和FOUR基因座之间存在显著的连锁不平衡。
